When you hear tenofovir, a nucleotide reverse transcriptase inhibitor used to suppress HIV and hepatitis B viruses. Also known as TDF or TAF, it's one of the most widely prescribed antiviral drugs in the world. It doesn’t cure HIV or hepatitis B, but it stops the virus from multiplying, which keeps your immune system strong and reduces liver damage. Millions of people rely on it daily—not because it’s flashy, but because it just works.
Tenofovir comes in two main forms: tenofovir disoproxil fumarate (TDF), the older version linked to kidney and bone density risks in some users, and tenofovir alafenamide (TAF), a newer, lower-dose version designed to reduce those side effects. Doctors often switch patients from TDF to TAF when they’re on long-term treatment, especially if they have kidney issues or osteoporosis. It’s not just about taking a pill—it’s about matching the right version to your body’s needs.
Tenofovir rarely works alone. It’s usually part of a combo pill with other antivirals like emtricitabine or elvitegravir. That’s because HIV mutates fast—if you use just one drug, the virus learns to fight back. These combo pills are why people on treatment can live long, healthy lives. For hepatitis B, tenofovir is often the first choice because it’s potent, has low resistance rates, and is safe for long-term use. But it’s not magic. You still need regular blood tests to check kidney function, liver health, and viral load. Skipping check-ups can turn a safe drug into a hidden problem.
Side effects? Most people feel fine, but some report nausea, headaches, or fatigue early on. A small number develop kidney stress or weakened bones over time. That’s why it’s not a drug you take and forget. You need to stay in touch with your doctor. And if you’re using it for prevention—like PrEP to avoid HIV—you still need testing every three months. Tenofovir won’t protect you from other STIs, and it won’t work if you miss doses.
What you’ll find below isn’t just a list of articles. It’s a real-world look at how tenofovir fits into bigger health stories: how it compares to other HIV meds, what alternatives exist when side effects hit, how it’s used in different populations, and what newer research is saying about long-term use. These aren’t generic summaries—they’re practical, no-fluff guides written by people who’ve seen the questions patients actually ask. Whether you’re starting tenofovir, switching from another drug, or just trying to understand why your doctor chose it, this collection gives you the facts without the jargon.
Tenofovir is a cornerstone treatment for chronic hepatitis B, suppressing the virus to prevent liver damage. Learn how it works, who benefits most, its side effects, and how it compares to other antivirals.
Health and Wellness