Azithromycin is a common antibiotic you’ve probably heard of as a “Z‑Pak.” Doctors use it for many bacterial infections — from ear infections and strep throat to some lung infections and certain sexually transmitted infections. But it’s not a cure‑all, and using it the right way matters for your safety and for fighting antibiotic resistance.
The classic Z‑Pak is 500 mg on day one, then 250 mg a day for the next four days. For chlamydia, a single 1 g dose is often given. Kids get doses based on weight — follow the doctor’s instructions or the pharmacy label. Take it with or without food; if it upsets your stomach, try taking it with a light meal.
Finish the full course even if you feel better early, unless your doctor tells you to stop. Stopping early can leave some bacteria alive and encourage resistance.
Most people tolerate azithromycin fine. The most common issues are nausea, stomach pain, diarrhea, and headaches. If you notice severe belly pain, persistent watery diarrhea, bloody stools, jaundice (yellow skin or eyes), or a rash with breathing trouble, stop the drug and seek medical help — these can be signs of serious problems like C. difficile infection, liver issues, or an allergic reaction.
Azithromycin can rarely affect heart rhythm. If you already have heart disease, take meds that affect your heartbeat, or have low potassium or magnesium, tell your doctor first.
Don’t use azithromycin for colds or most sore throats unless a doctor confirms a bacterial cause. Viral infections won’t respond, and unnecessary use drives resistance.
Drug interactions matter. Azithromycin can interact with blood thinners (like warfarin), some anti‑arrhythmics, and certain cholesterol drugs. Antacids with aluminum or magnesium can reduce how well the antibiotic is absorbed if taken at the same time — space them by a few hours. Always tell your provider about all meds and supplements you take.
If you’re pregnant or breastfeeding, azithromycin is often used when needed, but check with your provider — they’ll weigh risks and benefits for your situation. For infants and young children, dosing must be precise; never guess the amount.
Store azithromycin at room temperature, away from moisture and heat. Keep the suspension in the fridge only if the label or pharmacist tells you to, and shake well before measuring liquid doses.
Final practical tip: if symptoms don’t improve within 48–72 hours of starting treatment, or if they get worse, call your doctor. They may need to check for resistance, an alternate diagnosis, or a different medicine. Use antibiotics wisely — they work best when used correctly.
Health and Wellness